Publications

1

Deficiency of Aging-Related Gene Chitinase-Like 4 Impairs Olfactory Epithelium Homeostasis

Wu, T., Li, W., Zhuang, L., Liu, J., Wang, P., Gu, Y., Liu, Y., & Yu, Y. (2025)

Cell Prolif , 58 , e70055

https://doi.org/10.1111/cpr.70055
2

A single-cell transcriptomic census of mammalian olfactory epithelium aging

Li, W., Wu, T., Zhu, K., Ba, G., Liu, J., Zhou, P., Li, S., Wang, L., Liu, H., Ren, W., Yu, H., & Yu, Y. (2024)

Dev Cell , 59(22) , 3043–3058 e3048

https://doi.org/10.1016/j.devcel.2024.07.020
3

TMEM59 ablation leads to loss of olfactory sensory neurons and impairs olfactory functions via interaction with inflammation

Ma, Z., Li, W., Zhuang, L., Wen, T., Wang, P., Yu, H., Liu, Y., & Yu, Y. (2023)

Brain Behav Immun , 111 , 151–168

https://doi.org/10.1016/j.bbi.2023.04.005

1

Olfactory epithelium organoid models identify Ddit3 as a potential therapeutic target against inflammation-related olfactory sensory neuronal loss and functional deficit

Liu, J., Qi, J., Jiang, N., Wang, Y., Li, W., Tian, S., Zhuang, L., Zhang, Y., Liu, Y., & Yu, Y. (2026)

International Journal of Biological Sciences , 22(8) , 4025–4042

https://doi.org/10.7150/ijbs.129192
2

IL-17a induces age-related olfactory dysfunction by impairing regeneration and promoting respiratory metaplasia in mice

Wang, S., Cha, X., Xie, Y., Xu, Z., Cai, B., Li, F., Li, T., Wang, Z., Wang, T., Yu, Y., Liu, H., & Ren, W. (2025)

Nat Commun

https://doi.org/10.1038/s41467-025-67786-2
3

Establishment of nasal and olfactory epithelium organoids for unveiling mechanism of tissue regeneration and pathogenesis of nasal diseases

Liu, J., Zhang, Y., & Yu, Y. (2025)

Cell Mol Life Sci , 82 , 33

https://doi.org/10.1007/s00018-024-05557-w
4

Lgr5(+) cells are required and dynamically participate in olfactory epithelium regeneration: a revisiting shows Lgr5 expression in multiple cell lineages

Ren, W., Ma, Z., Wang, L., Feng, X., Yu, H., & Yu, Y. (2022)

Theranostics , 12(13) , 5631–5644

https://doi.org/10.7150/thno.60636
5

Expansion of murine and human olfactory epithelium/mucosa colonies and generation of mature olfactory sensory neurons under chemically defined conditions

Ren, W., Wang, L., Zhang, X., Feng, X., Zhuang, L., Jiang, N., Xu, R., Li, X., Wang, P., Sun, X., Yu, H., & Yu, Y. (2021)

Theranostics , 11(2) , 684

6

Chitinase-like protein Ym2 (Chil4) regulates regeneration of the olfactory epithelium via interaction with inflammation

Wang, L., Ren, W., Li, X., Zhang, X., Tian, H., Bhattarai, J. P., Challis, R. C., Lee, A. C., Zhao, S., Yu, H. & Yu, Y. (2021)

Journal of Neuroscience , 41(26) , 5620–5637

1

A midbrain-to-ventral-striatum dopaminergic pathway orchestrates odor-guided insect predation in mice

Wang, W., Zhong, Y., Tan, R., Wang, M., Liu, J., Wang, D., Wang, H., Li, Y., Li, G., Yang, J., Wang, P., Wu, J., Zhang, J., Wang, C. Z., Shi, H., Ma, M., Yu, Y., & Zhang, Y. F. (2025)

Proc Natl Acad Sci U S A , 122(41) , e2514847122

https://doi.org/10.1073/pnas.2514847122
2

Large-Scale G Protein-Coupled Olfactory Receptor-Ligand Pairing

Cong, X., Ren, W., Pacalon, J., Xu, R., Xu, L., Li, X., de March, C. A., Matsunami, H., Yu, H., Yu, Y., & Golebiowski, J. (2022)

ACS Cent Sci , 8(3) , 379–387

https://doi.org/10.1021/acscentsci.1c01495
3

Interactions among key residues regulate mammalian odorant receptor trafficking

Xu, R., Cong, X., Zheng, Q., Xu, L., Ni, M. J., de March, C. A., Matsunami, H., Golebiowski, J., Ma, M., & Yu, Y. (2022)

FASEB J , 36(7) , e22384

https://doi.org/10.1096/fj.202200116RR
4

Extracellular loop 2 of G protein-coupled olfactory receptors is critical for odorant recognition

Yu, Y., Ma, Z., Pacalon, J., Xu, L., Li, W., Belloir, C., Topin, J., Briand, L., Golebiowski, J., & Cong, X. (2022)

J Biol Chem , 298(9) , 102331

https://doi.org/10.1016/j.jbc.2022.102331
5

Zebrafish olfactory receptors ORAs differentially detect bile acids and bile salts

Cong, X., Zheng, Q., Ren, W., Cheron, J. B., Fiorucci, S., Wen, T., Zhang, C., Yu, H., Golebiowski, J., & Yu, Y. (2019)

J Biol Chem , 294(17) , 6762–6771

https://doi.org/10.1074/jbc.RA118.006483